Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
The structure was published by Lange, U.E., Bauke, D., Hornberger, W., Mack, H., Seitz, W., and Hoeffken, H.W., in 2003 in a paper entitled "D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.44 Å and deposited in 2003.
The experimental data on which the structure is based was not deposited.
This PDB entry contains a complex of 3 biomacromolecules, namely Thrombin light chain, Thrombin heavy chain, and Decapeptide Hirudin Analogue.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: