1o05 Summary

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Apo form of human mitochondrial aldehyde dehydrogenase

The structure was published by Hurley, T.D., Perez-Miller, S., and Breen, H., in 2001 in a paper entitled "Order and disorder in mitochondrial aldehyde dehydrogenase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Aldehyde dehydrogenase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%
B Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%
C Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%
D Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%
E Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%
F Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%
G Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%
H Aldehyde dehydrogenase P05091 (18-517) (ALDH2_HUMAN)search Homo sapienssearch 96% 500 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05091 (18 - 517) Aldehyde dehydrogenase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H (P05091) ALDH-likesearch Aldehyde Dehydrogenase; Chain A, domain 1search, Aldehyde Dehydrogenase; Chain A, domain 2search PF00171: Aldehyde dehydrogenase familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D, E, F, G, H (P05091) metabolic processsearch carbohydrate metabolic processsearch oxidation-reduction processsearch neurotransmitter biosynthetic processsearch synaptic transmissionsearch xenobiotic metabolic processsearch alcohol metabolic processsearch small molecule metabolic processsearch ethanol oxidationsearch ethanol catabolic processsearch aldehyde dehydrogenase (NAD) activitysearch oxidoreductase activitysearch oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorsearch aldehyde dehydrogenase [NAD(P)+] activitysearch electron carrier activitysearch mitochondrial matrixsearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Aldehyde dehydrogenase domainsearch Aldehyde dehydrogenase, cysteine active sitesearch Aldehyde/histidinol dehydrogenasesearch Aldehyde dehydrogenase N-terminal domainsearch Aldehyde dehydrogenase, C-terminalsearch Aldehyde dehydrogenase, glutamic acid active sitesearch