› 1nzp

Solution NMR

Solution Structure of the Lyase Domain of Human DNA Polymerase Lambda

Released:
DOI: 10.2210/pdb1nzp/pdb
PDB entry 1nzp coloured by chain, ensemble of 8 models, front view.
PDB entry 1nzp coloured by chain, ensemble of 8 models, side view.
PDB entry 1nzp coloured by chain, ensemble of 8 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the lyase domain of human DNA polymerase lambda.
DeRose EF, Kirby TW, Mueller GA, Bebenek K, Garcia-Diaz M, Blanco L, Kunkel TA, London RE
Biochemistry 42 9564-74 (2003)
PMID: 12911298

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193722 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA polymerase lambda Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UGP5 (Residues: 242-327; Coverage: 15%)
Gene name: POLL
Sequence domains: Helix-hairpin-helix domain
Structure domains: DNA polymerase beta, N-terminal domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing torsion angle dynamics follow by cartesian dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structure-function studies of DNA polymerase lambda.
Garcia-Diaz et al. (2005)
4 more

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more