1ny3 Summary


Crystal structure of ADP bound to MAP KAP kinase 2

The structure was published by Underwood, K.W., Parris, K.D., Federico, E., et al., Seehra, J., Somers, W.S., and Stahl, M.L., in 2003 in a paper entitled "Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MAP kinase-activated protein kinase 2. This molecule has the UniProt identifier P49137 (MAPK2_HUMAN)search. The sample contained 400 residues which is 100% of the natural sequence. Out of 400 residues 269 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP kinase-activated protein kinase 2 P49137 (1-400) (MAPK2_HUMAN)search Homo sapienssearch 100% 400 69%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49137 (1 - 400) MAP kinase-activated protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P49137) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P49137) protein phosphorylationsearch regulation of interleukin-6 productionsearch response to stresssearch activation of MAPK activitysearch stress-activated MAPK cascadesearch inflammatory responsesearch toll-like receptor 9 signaling pathwaysearch response to cytokinesearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch cellular response to DNA damage stimulussearch toll-like receptor 2 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch gene expressionsearch arachidonic acid metabolic processsearch toll-like receptor 4 signaling pathwaysearch cellular response to heatsearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of tumor necrosis factor productionsearch toll-like receptor 3 signaling pathwaysearch response to lipopolysaccharidesearch toll-like receptor 10 signaling pathwaysearch G2 DNA damage checkpointsearch phosphorylationsearch MAPK cascadesearch inner ear developmentsearch peptidyl-serine phosphorylationsearch macropinocytosissearch 3'-UTR-mediated mRNA stabilizationsearch leukotriene metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch mRNA stabilizationsearch regulation of cellular response to heatsearch Ras protein signal transductionsearch neurotrophin TRK receptor signaling pathwaysearch small molecule metabolic processsearch innate immune responsesearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch transferase activitysearch nucleotide bindingsearch kinase activitysearch signal transducer activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleussearch nucleoplasmsearch cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch MAP kinase activated protein kinase, C-terminal domainsearch