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Structure of Calpain Domain 6 in Complex with Calpastatin DIC

X-ray diffraction
2.3Å resolution
PDB entry 1nx0 coloured by chain, front view.
PDB entry 1nx0 coloured by chain, side view.
PDB entry 1nx0 coloured by chain, top view.
Source organism: Sus scrofa
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 16431.92 Å2
Buried surface area: 7974.47 Å2
Dissociation area: 358.69 Å2
Dissociation energy (ΔGdiss): 0.15 kcal/mol
Dissociation entropy (TΔSdiss): 4.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137920

Macromolecules

Calpain small subunit 1
Chains: A, B
Length: 173 amino acids
Theoretical weight: 19.88 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: P04574 (Residues: 94-266; Coverage: 65%)
Gene names: CAPN4, CAPNS1
InterPro:
CATH: EF-hand
SCOP: Penta-EF-hand proteins
Calpain small subunit 1 in PDB entry 1nx0, assembly 1, front view.
Calpain small subunit 1 in PDB entry 1nx0, assembly 1, side view.
Calpain small subunit 1 in PDB entry 1nx0, assembly 1, top view.
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Calpastatin
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.24 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: P12675 (Residues: 231-242; Coverage: 2%)
Gene name: CAST
Calpastatin in PDB entry 1nx0, assembly 1, front view.
Calpastatin in PDB entry 1nx0, assembly 1, side view.
Calpastatin in PDB entry 1nx0, assembly 1, top view.
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Small molecule inhibitor
Chain: E
Length: 5 amino acids
Theoretical weight: 474 Da
Small molecule inhibitor in PDB entry 1nx0, assembly 1, front view.
Small molecule inhibitor in PDB entry 1nx0, assembly 1, side view.
Small molecule inhibitor in PDB entry 1nx0, assembly 1, top view.
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