› 1nwr

X-ray diffraction
2.7Å resolution

Crystal structure of human cartilage gp39 (HC-gp39)

Released:
DOI: 10.2210/pdb1nwr/pdb
PDB entry 1nwr coloured by chain, front view.
PDB entry 1nwr coloured by chain, side view.
PDB entry 1nwr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
Fusetti F, Pijning T, Kalk KH, Bos E, Dijkstra BW
J Biol Chem 278 37753-60 (2003)
PMID: 12851408

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153156 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Chitinase-3-like protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 362 amino acids
Theoretical weight: 40.54 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P36222 (Residues: 22-383; Coverage: 100%)
Gene name: CHI3L1
Sequence domains: Glycosyl hydrolases family 18
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P43
Unit cell:
a: 127.3Å b: 127.3Å c: 107.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.239
Expression system: Cricetulus griseus

Quick links

Citations

29 review citations

Helminth parasites--masters of regulation.
Maizels et al. (2004)
28 more

7 mentions without citation

Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases.
Zhao et al. (2023)
6 more