1nwq Summary

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CRYSTAL STRUCTURE OF C/EBPALPHA-DNA COMPLEX

The structure was published by Miller, M., Shuman, J.D., Sebastian, T., Dauter, Z., and Johnson, P.F., in 2003 in a paper entitled "Structural Basis for DNA Recognition by the Basic Region Leucine Zipper Transcription Factor CCAAT/enhancer Binding Protein Alpha" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*TP*TP*CP*CP*TP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*CP*CP*AP*GP*TP*T)-3', 5'-D(*AP*AP*AP*CP*TP*GP*GP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*AP*GP*GP*A)-3', and CCAAT/enhancer binding protein alpha.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CCAAT/enhancer binding protein alpha P05554 (281-340) (CEBPA_RAT)search Rattus norvegicussearch < 90% 62 96%
C CCAAT/enhancer binding protein alpha P05554 (281-340) (CEBPA_RAT)search Rattus norvegicussearch < 90% 62 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05554 (281 - 340) CCAAT/enhancer binding protein alpha Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Basic region leucine zippersearch

Chain ID Molecular function (GO) Biological process (GO)
A, C (P05554) sequence-specific DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, C Basic-leucine zipper domainsearch