1nw9 Summary

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STRUCTURE OF CASPASE-9 IN AN INHIBITORY COMPLEX WITH XIAP-BIR3

The structure was published by Shiozaki, E.N., Chai, J., Rigotti, D.J., et al., Alnemri, E.S., Fairman, R., and Shi, Y., in 2003 in a paper entitled "Mechanism of XIAP-Mediated Inhibition of Caspase-9" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Baculoviral IAP repeat-containing protein 4 and caspase 9, apoptosis-related cysteine protease.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Baculoviral IAP repeat-containing protein 4 P98170 (253-350) (XIAP_HUMAN)search Homo sapienssearch < 90% 98 92%
B caspase 9, apoptosis-related cysteine protease P55211 (140-416) (CASP9_HUMAN)search Homo sapienssearch < 90% 277 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P98170 (253 - 350) Baculoviral IAP repeat-containing protein 4 Homo sapiens
P55211 (140 - 416) caspase 9, apoptosis-related cysteine protease Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Inhibitor of apoptosis (IAP) repeatsearch Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain Asearch Inhibitor of Apoptosis domainsearch
B Caspase catalytic domainsearch Rossmann foldsearch Caspase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
B (P55211) proteolysissearch apoptotic processsearch cysteine-type endopeptidase activitysearch cysteine-type peptidase activitysearch

Chain InterPro annotation
A Baculoviral inhibition of apoptosis protein repeatsearch
B Peptidase C14, ICE, catalytic subunit p20search Peptidase C14, caspase non-catalytic subunit p10search Peptidase C14, caspase domainsearch Peptidase C14A, caspase precursor p45, coresearch Peptidase C14, ICE, catalytic subunit p20, active sitesearch Caspase-like domainsearch