1nvt Summary


Crystal structure of Shikimate Dehydrogenase (AROE or MJ1084) in complex with NADP+

The structure was published by Padyana, A.K. and Burley, S.K., in 2003 in a paper entitled "Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Shikimate 5'-dehydrogenase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Shikimate 5'-dehydrogenase Q58484 (1-282) (AROE_METJA)search Methanocaldococcus jannaschii DSM 2661search 100% 287 100%
B Shikimate 5'-dehydrogenase Q58484 (1-282) (AROE_METJA)search Methanocaldococcus jannaschii DSM 2661search 100% 287 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q58484 (1 - 282) Shikimate 5'-dehydrogenase Methanocaldococcus jannaschii

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q58484) Aminoacid dehydrogenase-like, C-terminal domainsearch, Shikimate dehydrogenase-likesearch Leucine Dehydrogenase, chain A, domain 1search, NAD(P)-binding Rossmann-like Domainsearch PF01488: Shikimate / quinate 5-dehydrogenasesearch, PF08501: Shikimate dehydrogenase substrate binding domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q58484) shikimate 3-dehydrogenase (NADP+) activitysearch NADP bindingsearch oxidoreductase activitysearch aromatic amino acid family biosynthetic processsearch cellular amino acid biosynthetic processsearch chorismate biosynthetic processsearch oxidation-reduction processsearch shikimate metabolic processsearch

Chain InterPro annotation
A, B Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductasesearch Shikimate dehydrogenasesearch Shikimate dehydrogenase substrate binding, N-terminalsearch NAD(P)-binding domainsearch Shikimate, quinate/shikimate dehydrogenasesearch