1nvr Summary

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The Complex Structure Of Checkpoint Kinase Chk1/Staurosporine

The structure was published by Zhao, B., Bower, M.J., McDevitt, P.J., et al., Green, S.M., Concha, N.O., and Zhou, B.B., in 2002 in a paper entitled "Structural Basis for Chk1 Inhibition by UCN-01" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Serine/threonine-protein kinase Chk1 and Peptide ASVSA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase Chk1 O14757 (1-289) (CHK1_HUMAN)search Homo sapienssearch < 90% 289 91%
B Peptide ASVSA Not available
Not available Not available 5 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14757 (1 - 289) Serine/threonine-protein kinase Chk1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
B

Chain ID Molecular function (GO) Biological process (GO)
A (O14757) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B