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PDBe Entry: 1nvd 
Crystal structure of 3-dehydroquinate synthase (DHQS) in complex with ZN2+ and carbaphosphonate
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lyase
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X-RAY DIFFRACTION
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Resolution: 2.51 Å, R-factor: 19.6%, Free R-factor: 26.7%, Spacegroup: P 21 21 21
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18/03/2003, deposition: 03/02/2003, last revision: 24/02/2009
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Nichols, C.E.; Ren, J.; Lamb, H.K.; Hawkins, A.R.; Stammers, D.K.
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Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL. vol:327, pag:129-144 (2003) [PubMed ID 12614613 ]
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SHIKIMATE PATHWAY, AROMATIC AMINO ACID BIOSYNTHESIS, DHQS, open form, form B, DOMAIN MOVEMENT, CYCLASE, LYASE
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1.1.1.25 ExPASy BRENDA 2.5.1.19 ExPASy BRENDA 2.7.1.71 ExPASy BRENDA 4.2.1.10 ExPASy BRENDA 4.2.3.4 ExPASy BRENDA (A B)
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Emericella nidulans 162425(A B)
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Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (EC 2.7.1.71); 3-dehydroquinate dehydratase (EC 4.2.1.10) (3-dehydroquinase); Shikimate dehydrogenase (EC 1.1.1.25)] P07547 (A B)
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A, B
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1nr5, 1nrx, 1nve, 1nvb, 1nua, 1nva, 1nvf
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| A, B |
3-DEHYDROQUINATE SYNTHASE |
Protein |
P07547 (ARO1_EMENI)
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393 |
97% |
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| B, A |
ZINC ION |
ZN
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| A |
CHLORIDE ION |
CL
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| A, B |
[1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID |
CRB
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