1nuo Summary

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Two RTH Mutants with Impaired Hormone Binding

The structure was published by Huber, B.R., Sandler, B., West, B.L., et al., Apriletti, J.W., Baxter, J.D., and Fletterick, R.J., in 2003 in a paper entitled "Two resistance to thyroid hormone mutants with impaired hormone binding" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Thyroid hormone receptor beta-1. This molecule has the UniProt identifier P10828 (THB_HUMAN)search. The sample contained 261 residues which is < 90% of the natural sequence. Out of 261 residues 237 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Thyroid hormone receptor beta-1 P10828 (202-461) (THB_HUMAN)search Homo sapienssearch < 90% 261 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10828 (202 - 461) Thyroid hormone receptor beta-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P10828) nucleussearch regulation of transcription, DNA-dependentsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch DNA bindingsearch thyroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch