1nuf Summary


Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme

The structure was published by Ahvazi, B., Boeshans, K.M., Idler, W., Baxa, U., and Steinert, P.M., in 2003 in a paper entitled "Roles of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Protein-glutamine glutamyltransferase E. This molecule has the UniProt identifier Q08188 (TGM3_HUMAN)search. The sample contained 692 residues which is 100% of the natural sequence. Out of 692 residues 675 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein-glutamine glutamyltransferase E Q08188 (2-693) (TGM3_HUMAN)search Homo sapienssearch 100% 692 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q08188 (2 - 693) Protein-glutamine glutamyltransferase E Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q08188) Transglutaminase N-terminal domainsearch, Transglutaminase, two C-terminal domainssearch, Transglutaminase coresearch Immunoglobulinssearch, Coagulation Factor XIII, subunit A, domain 2search PF00868: Transglutaminase familysearch, PF00927: Transglutaminase family, C-terminal ig like domainsearch, PF01841: Transglutaminase-like superfamilysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q08188) peptide cross-linkingsearch keratinocyte differentiationsearch keratinizationsearch cell envelope organizationsearch hair follicle morphogenesissearch protein tetramerizationsearch cellular protein modification processsearch extrinsic component of cytoplasmic side of plasma membranesearch cytoplasmsearch extracellular vesicular exosomesearch protein-glutamine gamma-glutamyltransferase activitysearch transferase activity, transferring acyl groupssearch metal ion bindingsearch transferase activitysearch calcium ion bindingsearch catalytic activitysearch

Chain InterPro annotation
A Transglutaminase, N-terminalsearch Transglutaminase-likesearch Transglutaminase, C-terminalsearch Immunoglobulin-like foldsearch Transglutaminase, conserved sitesearch Immunoglobulin E-setsearch Protein-glutamine gamma-glutamyltransferase, eukaryotasearch