1nud Summary

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Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (3 calciums, active form)

The structure was published by Ahvazi, B., Boeshans, K.M., Idler, W., Baxa, U., and Steinert, P.M., in 2003 in a paper entitled "Roles of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Protein-glutamine glutamyltransferase E.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein-glutamine glutamyltransferase E Q08188 (2-693) (TGM3_HUMAN)search Homo sapienssearch 100% 692 97%
B Protein-glutamine glutamyltransferase E Q08188 (2-693) (TGM3_HUMAN)search Homo sapienssearch 100% 692 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q08188 (2 - 693) Protein-glutamine glutamyltransferase E Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q08188) Transglutaminase N-terminal domainsearch, Transglutaminase, two C-terminal domainssearch, Transglutaminase coresearch Immunoglobulinssearch, Coagulation Factor XIII, subunit A, domain 2search PF00868: Transglutaminase familysearch, PF00927: Transglutaminase family, C-terminal ig like domainsearch, PF01841: Transglutaminase-like superfamilysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q08188) peptide cross-linkingsearch protein tetramerizationsearch hair follicle morphogenesissearch cellular protein modification processsearch keratinizationsearch keratinocyte differentiationsearch cell envelope organizationsearch protein-glutamine gamma-glutamyltransferase activitysearch metal ion bindingsearch transferase activitysearch catalytic activitysearch calcium ion bindingsearch transferase activity, transferring acyl groupssearch cytoplasmsearch extracellular vesicular exosomesearch extrinsic component of cytoplasmic side of plasma membranesearch

Chain InterPro annotation
A, B Transglutaminase, N-terminalsearch Transglutaminase-likesearch Transglutaminase, C-terminalsearch Immunoglobulin-like foldsearch Transglutaminase, conserved sitesearch Immunoglobulin E-setsearch Protein-glutamine gamma-glutamyltransferase, eukaryotasearch