1nsi Summary

pdbe.org/1nsi
spacer

HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE, ZN-BOUND, L-ARG COMPLEX

The structure was published by Li, H., Raman, C.S., Glaser, C.B., et al., Parkinson, J.F., Whitlow, M., and Poulos, T.L., in 1999 in a paper entitled "Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (NITRIC OXIDE SYNTHASE).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (NITRIC OXIDE SYNTHASE) P35228 (74-504) (NOS2_HUMAN)search Homo sapienssearch < 90% 431 97%
B PROTEIN (NITRIC OXIDE SYNTHASE) P35228 (74-504) (NOS2_HUMAN)search Homo sapienssearch < 90% 431 97%
C PROTEIN (NITRIC OXIDE SYNTHASE) P35228 (74-504) (NOS2_HUMAN)search Homo sapienssearch < 90% 431 97%
D PROTEIN (NITRIC OXIDE SYNTHASE) P35228 (74-504) (NOS2_HUMAN)search Homo sapienssearch < 90% 431 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35228 (74 - 504) PROTEIN (NITRIC OXIDE SYNTHASE) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Nitric oxide (NO) synthase oxygenase domainsearch Nitric Oxide Synthase; Chain A, domain 1search, Nitric Oxide Synthase;Heme Domain;Chain A domain 2search, Nitric Oxide Synthase; Chain A, domain 3search Nitric oxide synthase, oxygenase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D (P35228) nitric oxide biosynthetic processsearch oxidation-reduction processsearch nitric-oxide synthase activitysearch

Chain InterPro annotation
A, B, C, D Nitric oxide synthase, N-terminalsearch