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Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase.

Li H, Raman CS, Glaser CB, Blasko E, Young TA, Parkinson JF, Whitlow M, Poulos TL
J Biol Chem 274 21276-84 (1999)
Cited: 120 times
EuropePMC logo PMID: 10409685

Abstract

The crystal structures of the heme domain of human inducible nitric-oxide synthase (NOS-2) in zinc-free and -bound states have been solved. In the zinc-free structure, two symmetry-related cysteine residues form a disulfide bond. In the zinc-bound state, these same two cysteine residues form part of a zinc-tetrathiolate (ZnS(4)) center indistinguishable from that observed in the endothelial isoform (NOS-3). As in NOS-3, ZnS(4) plays a key role in stabilizing intersubunit contacts and in maintaining the integrity of the cofactor (tetrahydrobiopterin) binding site of NOS-2. A comparison of NOS-2 and NOS-3 structures illustrates the conservation of quaternary structure, tertiary topology, and substrate and cofactor binding sites, in addition to providing insights on isoform-specific inhibitor design. The structural comparison also reveals that pterin binding does not preferentially stabilize the dimer interface of NOS-2 over NOS-3.

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  2. Evaluating caveolin interactions: do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif? Byrne DP, Dart C, Rigden DJ. PLoS One 7 e44879 (2012)
  3. Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase. Astashkin AV, Elmore BO, Fan W, Guillemette JG, Feng C. J Am Chem Soc 132 12059-12067 (2010)
  4. Electronic structure, ionization potential, and electron affinity of the enzyme cofactor (6R)-5,6,7,8-tetrahydrobiopterin in the gas phase, solution, and protein environments. Gogonea V, Shy JM, Biswas PK. J Phys Chem B 110 22861-22871 (2006)
  5. Taheebo Polyphenols Attenuate Free Fatty Acid-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of Cyclooxygenase-2. Ma S, Yada K, Lee H, Fukuda Y, Iida A, Suzuki K. Front Nutr 4 63 (2017)
  6. The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Li H, Jamal J, Delker S, Plaza C, Ji H, Jing Q, Huang H, Kang S, Silverman RB, Poulos TL. Biochemistry 53 5272-5279 (2014)
  7. Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics study. Sheng Y, Zhong L, Guo D, Lau G, Feng C. J Inorg Biochem 153 186-196 (2015)
  8. Food-related compounds that modulate expression of inducible nitric oxide synthase may act as its inhibitors. Maldonado-Rojas W, Olivero-Verbel J. Molecules 17 8118-8135 (2012)
  9. Identified the Synergistic Mechanism of Drynariae Rhizoma for Treating Fracture Based on Network Pharmacology. Lin H, Wang X, Wang L, Dong H, Huang P, Cai Q, Mo Y, Huang F, Jiang Z. Evid Based Complement Alternat Med 2019 7342635 (2019)
  10. Molecular docking, pharmacokinetic studies, and in vivo pharmacological study of indole derivative 2-(5-methoxy-2-methyl-1H-indole-3-yl)-N'-[(E)-(3-nitrophenyl) methylidene] acetohydrazide as a promising chemoprotective agent against cisplatin induced organ damage. Razak S, Afsar T, Bibi N, Abulmeaty M, Qamar W, Almajwal A, Inam A, Al Disi D, Shabbir M, Bhat MA. Sci Rep 11 6245 (2021)
  11. Elucidating nitric oxide synthase domain interactions by molecular dynamics. Hollingsworth SA, Holden JK, Li H, Poulos TL. Protein Sci 25 374-382 (2016)
  12. A polarizable force-field model for quantum-mechanical-molecular-mechanical Hamiltonian using expansion of point charges into orbitals. Biswas PK, Gogonea V. J Chem Phys 129 154108 (2008)
  13. A docked state conformational dynamics model to explain the ionic strength dependence of FMN - heme electron transfer in nitric oxide synthase. Astashkin AV, Li J, Zheng H, Miao Y, Feng C. J Inorg Biochem 184 146-155 (2018)
  14. Network Pharmacology and Metabolomics Studies on Antimigraine Mechanisms of Da Chuan Xiong Fang (DCXF). Ma S, Zheng L, Lin X, Feng Y, Yang M, Shen L. Evid Based Complement Alternat Med 2021 6665137 (2021)
  15. Dissecting structural and electronic effects in inducible nitric oxide synthase. Hannibal L, Page RC, Haque MM, Bolisetty K, Yu Z, Misra S, Stuehr DJ. Biochem J 467 153-165 (2015)
  16. Pulsed ENDOR determination of relative orientation of g-frame and molecular frame of imidazole-coordinated heme center of iNOS. Astashkin AV, Fan W, Elmore BO, Guillemette JG, Feng C. J Phys Chem A 115 10345-10352 (2011)
  17. Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect. Rubiolo JA, Lence E, González-Bello C, Roel M, Gil-Longo J, Campos-Toimil M, Ternon E, Thomas OP, González-Cantalapiedra A, López-Alonso H, Vieytes MR, Botana LM. Front Pharmacol 12 694639 (2021)
  18. Bioactive Compounds and Signaling Pathways of Wolfiporia extensa in Suppressing Inflammatory Response by Network Pharmacology. Jin J, Chowdhury MHU, Hafizur Rahman M, Choi KY, Adnan M. Life (Basel) 13 893 (2023)
  19. L-arginine binding to human inducible nitric oxide synthase: an antisymmetric funnel route toward isoform-specific inhibitors? Floquet N, Hernandez JF, Boucher JL, Martinez J. J Chem Inf Model 51 1325-1335 (2011)
  20. Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect. Attallah NGM, Kabbash A, Negm WA, Elekhnawy E, Binsuwaidan R, Al-Fakhrany OM, Shaldam MA, Moglad E, Tarek M, Samir N, Fawzy HM. Pharmaceuticals (Basel) 16 318 (2023)
  21. Protein Expression Profiling and Virtual Drug Screening as an Approach for Individualized Therapy of Small Cell Vaginal Carcinoma. Saeed MEM, Khalid HE, Thakur SK, Efferth T. Cancer Genomics Proteomics 19 512-525 (2022)
  22. The Role of Heme Peroxo Oxidants in the Rational Mechanistic Modeling of Nitric Oxide Synthase: Characterization of Key Intermediates and Elucidation of the Mechanism. Mondal P, Ishigami I, Yeh SR, Wijeratne GB. Angew Chem Int Ed Engl 61 e202211521 (2022)
  23. Insights into human eNOS, nNOS and iNOS structures and medicinal indications from statistical analyses of their interactions with bound compounds. Dong J, Li D, Kang L, Luo C, Wang J. Biophys Rep 9 159-175 (2023)
  24. Integrated Mechanisms of Polarity-Based Extracts of Cucumis melo L. Seed Kernels for Airway Smooth Muscle Relaxation via Key Signaling Pathways Based on WGCNA, In Vivo, and In Vitro Analyses. Wahid M, Saqib F, Ali A, Alshammari A, Alharbi M, Rauf A, Mubarak MS. Pharmaceuticals (Basel) 15 1522 (2022)
  25. Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition. Cao J, Li L, Zhang R, Shu Z, Zhang Y, Sun W, Zhang Y, Hu Z. Nat Prod Bioprospect 14 17 (2024)
  26. Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans. Castro-Sierra I, Duran-Izquierdo M, Sierra-Marquez L, Ahumedo-Monterrosa M, Olivero-Verbel J. Toxics 12 51 (2024)


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  1. Nitric oxide synthases: structure, function and inhibition. Alderton WK, Cooper CE, Knowles RG. Biochem J 357 593-615 (2001)
  2. Nitric oxide synthases: regulation and function. Förstermann U, Sessa WC. Eur Heart J 33 829-37, 837a-837d (2012)
  3. Role of oxidative modifications in atherosclerosis. Stocker R, Keaney JF. Physiol Rev 84 1381-1478 (2004)
  4. Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery. Paulsen CE, Carroll KS. Chem Rev 113 4633-4679 (2013)
  5. Heme enzyme structure and function. Poulos TL. Chem Rev 114 3919-3962 (2014)
  6. Nitric oxide and oxidative stress in vascular disease. Förstermann U. Pflugers Arch 459 923-939 (2010)
  7. Life history of eNOS: partners and pathways. Dudzinski DM, Michel T. Cardiovasc Res 75 247-260 (2007)
  8. NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets. Zhang Y, Murugesan P, Huang K, Cai H. Nat Rev Cardiol 17 170-194 (2020)
  9. Blocking NO synthesis: how, where and why? Vallance P, Leiper J. Nat Rev Drug Discov 1 939-950 (2002)
  10. Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Kone BC, Kuncewicz T, Zhang W, Yu ZY. Am J Physiol Renal Physiol 285 F178-90 (2003)
  11. Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal. Förstermann U. Biol Chem 387 1521-1533 (2006)
  12. Insight into protein structure and protein-ligand recognition by Fourier transform infrared spectroscopy. Jung C. J Mol Recognit 13 325-351 (2000)
  13. Zinc and immunoresistance to infection in aging: new biological tools. Mocchegiani E, Muzzioli M, Giacconi R. Trends Pharmacol Sci 21 205-208 (2000)
  14. Arginine and Endothelial Function. Gambardella J, Khondkar W, Morelli MB, Wang X, Santulli G, Trimarco V. Biomedicines 8 E277 (2020)
  15. Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain. Mukherjee P, Cinelli MA, Kang S, Silverman RB. Chem Soc Rev 43 6814-6838 (2014)
  16. Nitric oxide synthesis in the kidney: isoforms, biosynthesis, and functions in health. Kone BC. Semin Nephrol 24 299-315 (2004)
  17. Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response. Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Tesei S, Malavolta M. Mech Ageing Dev 127 517-525 (2006)
  18. Zinc, infections and immunosenescence. Mocchegiani E, Giacconi R, Muzzioli M, Cipriano C. Mech Ageing Dev 121 21-35 (2000)
  19. Is survival possible without arachidonate metabolites in the brain during systemic infection? Zhang J, Rivest S. News Physiol Sci 18 137-142 (2003)
  20. Melatonin interferes with COVID-19 at several distinct ROS-related steps. Camp OG, Bai D, Gonullu DC, Nayak N, Abu-Soud HM. J Inorg Biochem 223 111546 (2021)
  21. Computational Structural Biology of S-nitrosylation of Cancer Targets. Bignon E, Allega MF, Lucchetta M, Tiberti M, Papaleo E. Front Oncol 8 272 (2018)
  22. Modulating the NO generating system from a medicinal chemistry perspective: current trends and therapeutic options in cardiovascular disease. Schade D, Kotthaus J, Clement B. Pharmacol Ther 126 279-300 (2010)
  23. Nitric oxide synthase and structure-based inhibitor design. Poulos TL, Li H. Nitric Oxide 63 68-77 (2017)
  24. Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications. Andrabi SM, Sharma NS, Karan A, Shahriar SMS, Cordon B, Ma B, Xie J. Adv Sci (Weinh) 10 e2303259 (2023)
  25. Protein-protein interactions involving inducible nitric oxide synthase. Zhang W, Kuncewicz T, Yu ZY, Zou L, Xu X, Kone BC. Acta Physiol Scand 179 137-142 (2003)
  26. Structures of redox enzymes. Munro AW, Taylor P, Walkinshaw MD. Curr Opin Biotechnol 11 369-376 (2000)
  27. Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents. Matter H, Kotsonis P. Med Res Rev 24 662-684 (2004)
  28. A review of nitric oxide and oxidative stress in typical ovulatory women and in the pathogenesis of ovulatory dysfunction in PCOS. Awonuga AO, Camp OG, Abu-Soud HM. Reprod Biol Endocrinol 21 111 (2023)
  29. Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging. Carretero VJ, Ramos E, Segura-Chama P, Hernández A, Baraibar AM, Álvarez-Merz I, Muñoz FL, Egea J, Solís JM, Romero A, Hernández-Guijo JM. Antioxidants (Basel) 12 1844 (2023)
  30. Zinc homeostasis and redox alterations in obesity. Franco C, Canzoniero LMT. Front Endocrinol (Lausanne) 14 1273177 (2023)

Articles citing this publication (63)

  1. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. Zou MH, Shi C, Cohen RA. J Clin Invest 109 817-826 (2002)
  2. CASTp: Computed Atlas of Surface Topography of proteins. Binkowski TA, Naghibzadeh S, Liang J. Nucleic Acids Res 31 3352-3355 (2003)
  3. S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity. Ravi K, Brennan LA, Levic S, Ross PA, Black SM. Proc Natl Acad Sci U S A 101 2619-2624 (2004)
  4. Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry. McMillan K, Adler M, Auld DS, Baldwin JJ, Blasko E, Browne LJ, Chelsky D, Davey D, Dolle RE, Eagen KA, Erickson S, Feldman RI, Glaser CB, Mallari C, Morrissey MM, Ohlmeyer MH, Pan G, Parkinson JF, Phillips GB, Polokoff MA, Sigal NH, Vergona R, Whitlow M, Young TA, Devlin JJ. Proc Natl Acad Sci U S A 97 1506-1511 (2000)
  5. Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. Panda K, Rosenfeld RJ, Ghosh S, Meade AL, Getzoff ED, Stuehr DJ. J Biol Chem 277 31020-31030 (2002)
  6. Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase. Hemmens B, Goessler W, Schmidt K, Mayer B. J Biol Chem 275 35786-35791 (2000)
  7. Zinc regulates iNOS-derived nitric oxide formation in endothelial cells. Cortese-Krott MM, Kulakov L, Opländer C, Kolb-Bachofen V, Kröncke KD, Suschek CV. Redox Biol 2 945-954 (2014)
  8. Heme distortion modulated by ligand-protein interactions in inducible nitric-oxide synthase. Li D, Stuehr DJ, Yeh SR, Rousseau DL. J Biol Chem 279 26489-26499 (2004)
  9. Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus. Bird LE, Ren J, Zhang J, Foxwell N, Hawkins AR, Charles IG, Stammers DK. Structure 10 1687-1696 (2002)
  10. Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes. Fedorov R, Ghosh DK, Schlichting I. Arch Biochem Biophys 409 25-31 (2003)
  11. Metalloproteomics: principles, challenges and applications to neurodegeneration. Lothian A, Hare DJ, Grimm R, Ryan TM, Masters CL, Roberts BR. Front Aging Neurosci 5 35 (2013)
  12. Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms. Fedorov R, Hartmann E, Ghosh DK, Schlichting I. J Biol Chem 278 45818-45825 (2003)
  13. Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide. Kotsonis P, Fröhlich LG, Shutenko ZV, Horejsi R, Pfleiderer W, Schmidt HH. Biochem J 346 Pt 3 767-776 (2000)
  14. The journey from NADPH-cytochrome P450 oxidoreductase to nitric oxide synthases. Masters BS. Biochem Biophys Res Commun 338 507-519 (2005)
  15. Conformational changes in redox pairs of protein structures. Fan SW, George RA, Haworth NL, Feng LL, Liu JY, Wouters MA. Protein Sci 18 1745-1765 (2009)
  16. Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes. Loughran PA, Stolz DB, Vodovotz Y, Watkins SC, Simmons RL, Billiar TR. Proc Natl Acad Sci U S A 102 13837-13842 (2005)
  17. Inhibition of nitric oxide synthase isoforms by tris-malonyl-C(60)-fullerene adducts. Wolff DJ, Papoiu AD, Mialkowski K, Richardson CF, Schuster DI, Wilson SR. Arch Biochem Biophys 378 216-223 (2000)
  18. Intracellular formation of "undisruptable" dimers of inducible nitric oxide synthase. Kolodziejski PJ, Rashid MB, Eissa NT. Proc Natl Acad Sci U S A 100 14263-14268 (2003)
  19. Structural basis for isoform-selective inhibition in nitric oxide synthase. Poulos TL, Li H. Acc Chem Res 46 390-398 (2013)
  20. Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide. Li D, Hayden EY, Panda K, Stuehr DJ, Deng H, Rousseau DL, Yeh SR. J Biol Chem 281 8197-8204 (2006)
  21. Studying the S-nitrosylation of model peptides and eNOS protein by mass spectrometry. Taldone FS, Tummala M, Goldstein EJ, Ryzhov V, Ravi K, Black SM. Nitric Oxide 13 176-187 (2005)
  22. Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response. Lajoix AD, Pugnière M, Roquet F, Mani JC, Dietz S, Linck N, Faurie F, Ribes G, Petit P, Gross R. Diabetes 53 1467-1474 (2004)
  23. Structures of human constitutive nitric oxide synthases. Li H, Jamal J, Plaza C, Pineda SH, Chreifi G, Jing Q, Cinelli MA, Silverman RB, Poulos TL. Acta Crystallogr D Biol Crystallogr 70 2667-2674 (2014)
  24. Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors. Ji H, Gómez-Vidal JA, Martasek P, Roman LJ, Silverman RB. J Med Chem 49 6254-6263 (2006)
  25. L-arginine analogs as alternate substrates for nitric oxide synthase. Luzzi SD, Marletta MA. Bioorg Med Chem Lett 15 3934-3941 (2005)
  26. Reduced bactericidal activity and nitric oxide production in metallothionein-deficient macrophages in response to lipopolysaccharide stimulation. Itoh N, Shibayama H, Kanekiyo M, Namphung D, Nakanishi T, Matsuyama A, Odani T, Tanaka K. Toxicology 216 188-196 (2005)
  27. Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas. Li H, Raman CS, Martásek P, Král V, Masters BS, Poulos TL. J Inorg Biochem 81 133-139 (2000)
  28. Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Mukherjee P, Li H, Sevrioukova I, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. J Med Chem 58 1067-1088 (2015)
  29. The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS. Wheatley C. J Nutr Environ Med 16 181-211 (2007)
  30. Nitric oxide synthase activation and oxidative stress, but not intracellular zinc dyshomeostasis, regulate ultraviolet B light-induced apoptosis. Wang L, Liu W, Parker SH, Wu S. Life Sci 86 448-454 (2010)
  31. Peroxynitrite-Mediated SIRT (Sirtuin)-1 Inactivation Contributes to Nicotine-Induced Arterial Stiffness in Mice. Ding Y, Han Y, Lu Q, An J, Zhu H, Xie Z, Song P, Zou MH. Arterioscler Thromb Vasc Biol 39 1419-1431 (2019)
  32. Structure-based design of bacterial nitric oxide synthase inhibitors. Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. J Med Chem 58 994-1004 (2015)
  33. Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase. Chreifi G, Li H, McInnes CR, Gibson CL, Suckling CJ, Poulos TL. Biochemistry 53 4216-4223 (2014)
  34. Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles. Schumann P, Collot V, Hommet Y, Gsell W, Dauphin F, Sopkova J, MacKenzie ET, Duval D, Boulouard M, Rault S. Bioorg Med Chem Lett 11 1153-1156 (2001)
  35. Subacute zinc administration and L-NAME caused an increase of NO, zinc, lipoperoxidation, and caspase-3 during a cerebral hypoxia-ischemia process in the rat. Blanco-Alvarez VM, Lopez-Moreno P, Soto-Rodriguez G, Martinez-Fong D, Rubio H, Gonzalez-Barrios JA, Piña-Leyva C, Torres-Soto M, Gomez-Villalobos Mde J, Hernandez-Baltazar D, Brambila E, Eguibar JR, Ugarte A, Cebada J, Leon-Chavez BA. Oxid Med Cell Longev 2013 240560 (2013)
  36. A nitric oxide synthase-like protein from Synechococcus produces NO/NO3- from l-arginine and NADPH in a tetrahydrobiopterin- and Ca2+-dependent manner. Picciano AL, Crane BR. J Biol Chem 294 10708-10719 (2019)
  37. Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. Do HT, Li H, Chreifi G, Poulos TL, Silverman RB. J Med Chem 62 2690-2707 (2019)
  38. Roles of the heme proximal side residues tryptophan409 and tryptophan421 of neuronal nitric oxide synthase in the electron transfer reaction. Yumoto T, Sagami I, Daff S, Shimizu T. J Inorg Biochem 82 163-170 (2000)
  39. 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. Maddaford S, Renton P, Speed J, Annedi SC, Ramnauth J, Rakhit S, Andrews J, Mladenova G, Majuta L, Porreca F. Bioorg Med Chem Lett 21 5234-5238 (2011)
  40. Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase. Noguchi T, Sagami I, Daff S, Shimizu T. Biochem Biophys Res Commun 282 1092-1097 (2001)
  41. Interaction between neuronal nitric-oxide synthase and tetrahydrobiopterin revisited: studies on the nature and mechanism of tight pterin binding. Heine CL, Kolesnik B, Schmidt R, Werner ER, Mayer B, Gorren AC. Biochemistry 53 1284-1295 (2014)
  42. Substrate-ligand interactions in Geobacillus stearothermophilus nitric oxide synthase. Kabir M, Sudhamsu J, Crane BR, Yeh SR, Rousseau DL. Biochemistry 47 12389-12397 (2008)
  43. A nanobiosensor for the detection of arginase activity. Malalasekera AP, Wang H, Samarakoon TN, Udukala DN, Yapa AS, Ortega R, Shrestha TB, Alshetaiwi H, McLaurin EJ, Troyer DL, Bossmann SH. Nanomedicine 13 383-390 (2017)
  44. Cobalamin in inflammation III - glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases. Wheatley C. J Nutr Environ Med 16 212-226 (2007)
  45. Collisional cooling enhances the ability to observe non-covalent interactions within the inducible nitric oxide synthase oxygenase domain: dimerization, complexation, and dissociation. Smith JC, Siu KW, Rafferty SP. J Am Soc Mass Spectrom 15 629-638 (2004)
  46. Design of benzene-1,2-diamines as selective inducible nitric oxide synthase inhibitors: a combined de novo design and docking analysis. Francis SM, Mittal A, Sharma M, Bharatam PV. J Mol Model 14 215-224 (2008)
  47. Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms. Oliveira BL, Moreira IS, Fernandes PA, Ramos MJ, Santos I, Correia JD. J Mol Model 19 1537-1551 (2013)
  48. Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties. Palumbo A, Napolitano A, d'Ischia M. Bioorg Med Chem Lett 12 13-16 (2002)
  49. Unusual role of Tyr588 of neuronal nitric oxide synthase in controlling substrate specificity and electron transfer. Sato Y, Sagami I, Matsui T, Shimizu T. Biochem Biophys Res Commun 281 621-626 (2001)
  50. Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor. Ijuin R, Umezawa N, Higuchi T. Bioorg Med Chem 14 3563-3570 (2006)
  51. Protein engineering to develop a redox insensitive endothelial nitric oxide synthase. Rafikov R, Kumar S, Aggarwal S, Pardo D, Fonseca FV, Ransom J, Rafikova O, Chen Q, Springer ML, Black SM. Redox Biol 2 156-164 (2014)
  52. Synthesis, pharmacological study and modeling of 7-methoxyindazole and related substituted indazoles as neuronal nitric oxide synthase inhibitors. Collot V, Sopkova-de Oliveira Santos J, Schumann-Bard P, Colloc'h N, Mackenzie ET, Rault S. J Enzyme Inhib Med Chem 18 195-199 (2003)
  53. Thiouracil antithyroid drugs as a new class of neuronal nitric oxide synthase inhibitors. Palumbo A, d'Ischia M. Biochem Biophys Res Commun 282 793-797 (2001)
  54. Optical biosensing of markers of mucosal inflammation. Covarrubias-Zambrano O, Motamedi M, Ameredes BT, Tian B, Calhoun WJ, Zhao Y, Brasier AR, Kalubowilage M, Malalasekera AP, Yapa AS, Wang H, Culbertson CT, Troyer DL, Bossmann SH. Nanomedicine 40 102476 (2022)
  55. Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors. Erdal EP, Martásek P, Roman LJ, Silverman RB. Bioorg Med Chem 15 6096-6108 (2007)
  56. Insights into ligand selectivity in nitric oxide synthase isoforms: a molecular dynamics study. Aparna V, Desiraju GR, Gopalakrishnan B. J Mol Graph Model 26 457-470 (2007)
  57. Preferential recognition of undisruptable dimers of inducible nitric oxide synthase by a monoclonal antibody directed against an N-terminal epitope. Mazumdar T, Eissa NT. J Immunol 174 2314-2317 (2005)
  58. Titration of low K(d) binding sites: binding of arginine analogs to nitric oxide synthases. Smith SM, Sham C, Roman L, Martasek P, Salerno JC. Nitric Oxide 5 442-452 (2001)
  59. Critical role of the neuronal nitric-oxide synthase heme proximal side residue, Arg418, in catalysis and electron transfer. Sato Y, Sagami I, Shimizu T. J Inorg Biochem 87 261-266 (2001)
  60. Dissociation and unfolding of inducible nitric oxide synthase oxygenase domain identifies structural role of tetrahydrobiopterin in modulating the heme environment. Sengupta R, Sengupta R, Sahoo R, Ray SS, Dutta T, Dasgupta A, Ghosh S. Mol Cell Biochem 284 117-126 (2006)
  61. Expression and Distribution of Free Zinc in Penile Erectile Tissue. Kang BS, Suh SW, Yang DY, Choi BY, Lee WK. World J Mens Health 41 155-163 (2023)
  62. Network Pharmacology Integrated Molecular Docking and Dynamics to Elucidate Saffron Compounds Targeting Human COX-2 Protein. Ali A, Wani AB, Malla BA, Poyya J, Dar NJ, Ali F, Ahmad SB, Rehman MU, Nadeem A. Medicina (Kaunas) 59 2058 (2023)
  63. Fourier transform infrared spectroscopy study of ligand photodissociation and migration in inducible nitric oxide synthase. Horn M, Nienhaus K, Nienhaus GU. F1000Res 3 290 (2014)


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