1nrv Summary

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Crystal structure of the SH2 domain of Grb10

The structure was published by Stein, E.G., Ghirlando, R., and Hubbard, S.R., in 2003 in a paper entitled "Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.65 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Growth factor receptor-bound protein 10.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Growth factor receptor-bound protein 10 Q13322 (487-591) (GRB10_HUMAN)search Homo sapienssearch < 90% 105 95%
B Growth factor receptor-bound protein 10 Q13322 (487-591) (GRB10_HUMAN)search Homo sapienssearch < 90% 105 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13322 (487 - 591) Growth factor receptor-bound protein 10 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A, B SH2 domainsearch