› 1nrv

X-ray diffraction
1.65Å resolution

Crystal structure of the SH2 domain of Grb10

Released:
DOI: 10.2210/pdb1nrv/pdb
PDB entry 1nrv coloured by chain, front view.
PDB entry 1nrv coloured by chain, side view.
PDB entry 1nrv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
Stein EG, Ghirlando R, Hubbard SR
J Biol Chem 278 13257-64 (2003)
PMID: 12551896

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 105 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13322 (Residues: 487-591; Coverage: 18%)
Gene names: GRB10, GRBIR, KIAA0207
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 28.82Å b: 49.04Å c: 79.61Å
α: 90° β: 96.62° γ: 90°
R-values:
R R work R free
0.225 0.224 0.242
Expression system: Escherichia coli BL21

Quick links

Citations

9 review citations

Biochemical and cellular properties of insulin receptor signalling.
Haeusler et al. (2018)
8 more

9 mentions without citation

Templates are available to model nearly all complexes of structurally characterized proteins.
Kundrotas et al. (2012)
8 more