1nqp Summary

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Crystal structure of Human hemoglobin E at 1.73 A resolution

The structure was published by Dasgupta, J., Sen, U., Choudhury, D., et al., Chakrabarty, S.B., Chakrabarty, A., and Dattagupta, J.K., in 2004 in a paper entitled "Crystallization and preliminary X-ray structural Studies of Hemoglobin A2 and Hemoglobin E, isolated from the blood samples of Beta-thalassemic patients" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.73 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen bindingsearch heme bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch bicarbonate transportsearch positive regulation of cell deathsearch oxygen transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch
B, D (P68871) heme bindingsearch protein bindingsearch peroxidase activitysearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch oxygen transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch positive regulation of cell deathsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch renal absorptionsearch transportsearch regulation of blood pressuresearch platelet aggregationsearch regulation of blood vessel sizesearch blood coagulationsearch response to hydrogen peroxidesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch