1nqp Summary

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Crystal structure of Human hemoglobin E at 1.73 A resolution

The structure was published by Dasgupta, J., Sen, U., Choudhury, D., et al., Chakrabarty, S.B., Chakrabarty, A., and Dattagupta, J.K., in 2004 in a paper entitled "Crystallization and preliminary X-ray structural Studies of Hemoglobin A2 and Hemoglobin E, isolated from the blood samples of Beta-thalassemic patients" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.73 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch iron ion bindingsearch metal ion bindingsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular regionsearch blood microparticlesearch membranesearch bicarbonate transportsearch receptor-mediated endocytosissearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch oxygen transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch
B, D (P68871) protein bindingsearch oxygen bindingsearch peroxidase activitysearch heme bindingsearch oxygen transporter activitysearch iron ion bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch metal ion bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch oxygen transportsearch platelet aggregationsearch bicarbonate transportsearch renal absorptionsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch blood coagulationsearch protein heterooligomerizationsearch nitric oxide transportsearch oxidation-reduction processsearch transportsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch