1nql Summary


Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

The structure was published by Ferguson, K.M., Berger, M.B., Mendrola, J.M., Cho, H., Leahy, D.J., and Lemmon, M.A., in 2003 in a paper entitled "EGF activates its receptor by removing interactions that auto-inhibit ectodomain dimerization" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely epidermal growth factor receptor and epidermal growth factor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A epidermal growth factor receptor P00533 (25-642) (EGFR_HUMAN)search Homo sapienssearch < 90% 624 98%
B epidermal growth factor P01133 (971-1023) (EGF_HUMAN)search Homo sapienssearch < 90% 53 90%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00533 (25 - 642) epidermal growth factor receptor Homo sapiens
P01133 (971 - 1023) epidermal growth factor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A L domainsearch, Growth factor receptor domainsearch 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch
B EGF-type modulesearch Lamininsearch EGF-like domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00533) transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A EGF receptor, L domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch
B Epidermal growth factor-like domainsearch EGF-like, conserved sitesearch Epidermal growth factor receptor ligandsearch