1nqc Summary

pdbe.org/1nqc
spacer

Crystal structures of Cathepsin S inhibitor complexes

The structure was published by Pauly, T.A., Sulea, T., Ammirati, M., et al., Menard, R., Cygler, M., and Rath, V.L., in 2003 in a paper entitled "Specificity determinants of human cathepsin s revealed by crystal structures of complexes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cathepsin S. This molecule has the UniProt identifier P25774 (CATS_HUMAN)search. The sample contained 217 residues which is < 90% of the natural sequence. Out of 217 residues 217 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin S P25774 (115-331) (CATS_HUMAN)search Homo sapienssearch 100% 217 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P25774 (115 - 331) Cathepsin S Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P25774) Papain-likesearch Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P25774) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch