1nq7 Summary


Characterization of ligands for the orphan nuclear receptor RORbeta

The structure was published by Stehlin-Gaon, C., Willmann, D., Zeyer, D., et al., Renaud, J.-P., Moras, D., and Schuele, R., in 2003 in a paper entitled "All-trans retinoic acid is a ligand for the orphan nuclear receptor RORbeta" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely NUCLEAR RECEPTOR ROR-BETA and STEROID RECEPTOR COACTIVATOR-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NUCLEAR RECEPTOR ROR-BETA P45446 (219-462) (RORB_RAT)search Rattus norvegicussearch < 90% 244 100%
B STEROID RECEPTOR COACTIVATOR-1 Q15788 (687-696) (NCOA1_HUMAN)search Homo sapienssearch < 90% 10 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P45446 (219 - 462) NUCLEAR RECEPTOR ROR-BETA Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P45446) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch DNA bindingsearch nucleussearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear receptor RORsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear receptor coactivator Src-1search