1npq Summary

pdbe.org/1npq
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structure of a rhodamine-labeled N-domain Troponin C mutant (Ca2+ saturated) in complex with skeletal Troponin I 115-131

The structure was published by Mercier, P., Ferguson, R.E., Irving, M., Corrie, J.E.T., Trentham, D.R., and Sykes, B.D., in 2003 in a paper entitled "NMR Structure of a Bifunctional Rhodamine Labeled N-Domain of Troponin C Complexed with the Regulatory "Switch" Peptide from Troponin I: Implications for in Situ Fluorescence Studies in Muscle Fibers" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Troponin C and Troponin I.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Troponin C P02588 (2-91) (TNNC2_CHICK)search Gallus gallussearch 98% 90 100%
B Troponin I P02643 (116-132) (TNNI2_RABIT)search Oryctolagus cuniculussearch < 90% 17 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P02588 (2 - 91) Troponin C Gallus gallus
P02643 (116 - 132) Troponin I

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P02588) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B Troponinsearch

Chain ID Molecular function (GO)
A (P02588) calcium ion bindingsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B