1nmw Summary

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Solution structure of the PPIase domain of human Pin1

The structure was published by Bayer, E., Goettsch, S., Mueller, J.W., et al., Guiberman, E., Mayr, L.M., and Bayer, P., in 2003 in a paper entitled "Structural Analysis of the Mitotic Regulator hPin1 in Solution: INSIGHTS INTO DOMAIN ARCHITECTURE AND SUBSTRATE BINDING." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1. This molecule has the UniProt identifier Q13526 (PIN1_HUMAN)search. The sample contained 114 residues which is < 90% of the natural sequence. Out of 114 residues 114 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Q13526 (50-163) (PIN1_HUMAN)search Homo sapienssearch 97% 114 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13526 (50 - 163) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q13526) FKBP immunophilin/proline isomerasesearch Chitinase A; domain 3search PF00639: PPIC-type PPIASE domainsearch

Chain ID Molecular function (GO)
A (Q13526) isomerase activitysearch

Chain InterPro annotation
A Peptidyl-prolyl cis-trans isomerase, PpiC-typesearch Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved sitesearch