1nmb Summary

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THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY

The structure was published by Malby, R.L., Tulip, W.R., Harley, V.R., et al., Laver, W.G., Webster, R.G., and Colman, P.M., in 1994 in a paper entitled "The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely N9 NEURAMINIDASE and FAB NC10.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
N N9 NEURAMINIDASE P05803 (1-470) (NRAM_I84A1)search Influenza A virus (A/whale/Maine/1/84(H13N9))search 100% 470 82%
L FAB NC10 Not available
Mus musculussearch Not available 109 100%
H FAB NC10 Not available
Mus musculussearch Not available 122 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05803 (1 - 470) N9 NEURAMINIDASE Influenza A virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
N (P05803) Sialidases (neuraminidases)search Neuraminidasesearch PF00064: Neuraminidasesearch
L V set domains (antibody variable domain-like)search Immunoglobulinssearch
H V set domains (antibody variable domain-like)search Immunoglobulinssearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
N (P05803) exo-alpha-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch hydrolase activitysearch exo-alpha-(2->3)-sialidase activitysearch exo-alpha-(2->6)-sialidase activitysearch metal ion bindingsearch hydrolase activity, acting on glycosyl bondssearch membranesearch host cell membranesearch virion membranesearch virionsearch host cell plasma membranesearch integral component of membranesearch metabolic processsearch carbohydrate metabolic processsearch

Chain InterPro annotation
N Glycoside hydrolase, family 34search Sialidasessearch
L Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch