EC 3.2.1.18: Exo-alpha-sialidase
Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
- Acetylneuraminidase
- Alpha-neuraminidase
- N-acylneuraminate glycohydrolase
- Neuraminidase
- Sialidase
Protein family (Pfam)![The deposited structure of PDB entry 1nmb contains 1 copy of Pfam domain PF00064 (Neuraminidase) in Neuraminidase. Showing 1 copy in chain A [auth N].](https://www.ebi.ac.uk/pdbe/static/entry/1nmb_1_N_Pfam_PF00064_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1nmb</span> contains 1 copy of Pfam domain <span class='highlight'>PF00064 (Neuraminidase)</span> in <span class='highlight'>Neuraminidase</span>. Showing 1 copy in chain <span class='highlight'>A [auth N]</span>.")
InterPro annotations
CATH domains![The deposited structure of PDB entry 1nmb contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in FAB NC10. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1nmb_2_L_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1nmb</span> contains 1 copy of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>FAB NC10</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>.")
![The deposited structure of PDB entry 1nmb contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in FAB NC10. Showing 1 copy in chain C [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/1nmb_3_H_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1nmb</span> contains 1 copy of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>FAB NC10</span>. Showing 1 copy in chain <span class='highlight'>C [auth H]</span>.")
![The deposited structure of PDB entry 1nmb contains 1 copy of CATH domain 2.120.10.10 (Neuraminidase) in Neuraminidase. Showing 1 copy in chain A [auth N].](https://www.ebi.ac.uk/pdbe/static/entry/1nmb_1_N_CATH_2.120.10.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1nmb</span> contains 1 copy of CATH domain <span class='highlight'>2.120.10.10 (Neuraminidase)</span> in <span class='highlight'>Neuraminidase</span>. Showing 1 copy in chain <span class='highlight'>A [auth N]</span>.")
SCOP annotations![The deposited structure of PDB entry 1nmb contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in FAB NC10. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1nmb_2_L_SCOP_48727_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1nmb</span> contains 1 copy of SCOP domain <span class='highlight'>48727 (V set domains (antibody variable domain-like))</span> in <span class='highlight'>FAB NC10</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>.")
![The deposited structure of PDB entry 1nmb contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in FAB NC10. Showing 1 copy in chain C [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/1nmb_3_H_SCOP_48727_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1nmb</span> contains 1 copy of SCOP domain <span class='highlight'>48727 (V set domains (antibody variable domain-like))</span> in <span class='highlight'>FAB NC10</span>. Showing 1 copy in chain <span class='highlight'>C [auth H]</span>.")
![The deposited structure of PDB entry 1nmb contains 1 copy of SCOP domain 50940 (Sialidases (neuraminidases)) in Neuraminidase. Showing 1 copy in chain A [auth N].](https://www.ebi.ac.uk/pdbe/static/entry/1nmb_1_N_SCOP_50940_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1nmb</span> contains 1 copy of SCOP domain <span class='highlight'>50940 (Sialidases (neuraminidases))</span> in <span class='highlight'>Neuraminidase</span>. Showing 1 copy in chain <span class='highlight'>A [auth N]</span>.")