1nma Summary

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N9 NEURAMINIDASE COMPLEXES WITH ANTIBODIES NC41 AND NC10: EMPIRICAL FREE-ENERGY CALCULATIONS CAPTURE SPECIFICITY TRENDS OBSERVED WITH MUTANT BINDING DATA

The structure was published by Tulip, W.R., Harley, V.R., Webster, R.G., and Novotny, J., in 1994 in a paper entitled "N9 neuraminidase complexes with antibodies NC41 and NC10: empirical free energy calculations capture specificity trends observed with mutant binding data." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely N9 NEURAMINIDASE and FAB NC10.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
N N9 NEURAMINIDASE P05803 (83-470) (NRAM_I84A1)search Influenza A virus (A/whale/Maine/1/84(H13N9))search 100% 388 97%
L FAB NC10 Not available
Mus musculussearch Not available 109 100%
H FAB NC10 Not available
Mus musculussearch Not available 122 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05803 (83 - 470) N9 NEURAMINIDASE Influenza A virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
N (P05803) Sialidases (neuraminidases)search Neuraminidasesearch PF00064: Neuraminidasesearch
L V set domains (antibody variable domain-like)search Immunoglobulinssearch
H V set domains (antibody variable domain-like)search Immunoglobulinssearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
N (P05803) host cell membranesearch virion membranesearch membranesearch carbohydrate metabolic processsearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
N Glycoside hydrolase, family 34search Sialidasessearch
L Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch