spacer STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE
Primary citation
Title Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.
Authors Feng, S.search; Kapoor, T.M.search; Shirai, F.search; Combs, A.P.search; Schreiber, S.L.search
Journal CHEM.BIOL.search vol:3, pag:661-670 (1996), Identifiers: PubMed ID (8807900)search DOI (10.1016/S1074-5521(96)90134-9)
Abstract Protein-structure-based combinatorial chemistry has recently been used to discover several ligands containing non-peptide binding elements to the Src SH3 domain. The encoded library used has the form Cap-M1-M2-M3-PLPPLP, in which the Cap and Mi's are composed of a diverse set of organic monomers. The PLPPLP portion provided a structural bias directing the non-peptide fragment Cap-M1-M2-M3 to the SH3 specificity pocket. Fifteen ligands were selected from > 1.1 million distinct compounds. The structural basis for selection was unknown.
MeSH terms Amino Acid Sequencesearch, Binding Sitessearch, Drug Designsearch, Escherichia colisearch, Ligandssearch, Magnetic Resonance Spectroscopysearch, Modelssearch, Molecularsearch, Molecular Structuresearch, Mutationsearch, Protein Bindingsearch, Protein Conformationsearch, src Homology Domainssearch
Other entries described in this publication 1nlp
Secondary citations
Title Protein Structure-Based Combinatorial Chemistry: Discovery of Non-Peptide Binding Elements to Src SH3 Domain
Authors Combs, A.P.search; Kapoor, T.M.search; Feng, S.search; Chen, J.K.search; Daude-Snow, L.F.search; Schreiber, S.L.search
Journal J.AM.CHEM.SOC.search vol:118, pag:287 (1996)
Title Specific Interactions Outside the Proline-Rich Core of Two Classes of Src Homology 3 Ligands
Authors Feng, S.search; Kasahara, C.search; Rickles, R.J.search; Schreiber, S.L.search
Journal PROC.NATL.ACAD.SCI.USAsearch vol:92, pag:12408 (1995)
Title Structural Basis for the Binding of Proline-Rich Peptides to SH3 Domains
Authors Yu, H.search; Chen, J.K.search; Feng, S.search; Dalgarno, D.C.search; Brauer, A.W.search; Schreiber, S.L.search
Journal CELL(CAMBRIDGE,MASS.)search vol:76, pag:933 (1994)
Title Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions
Authors Feng, S.search; Chen, J.K.search; Yu, H.search; Simon, J.A.search; Schreiber, S.L.search
Journal SCIENCEsearch vol:266, pag:1241 (1994)
Title Solution Structure of the SH3 Domain of Src and Identification of its Ligand-Binding Site
Authors Yu, H.search; Rosen, M.K.search; Shin, T.B.search; Seidel-Dugan, C.search; Brugge, J.S.search; Schreiber, S.L.search
Journal SCIENCEsearch vol:258, pag:1665 (1992)
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