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Structure of deoxy-quaternary haemoglobin with liganded beta subunits

The structure was published by Luisi, B., Liddington, B., Fermi, G., and Shibayama, N., in 1990 in a paper entitled "Structure of deoxy-quaternary haemoglobin with liganded beta subunits." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1990.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) extracellular vesicular exosomesearch extracellular regionsearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch membranesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolsearch blood microparticlesearch protein bindingsearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch bicarbonate transportsearch oxygen transportsearch protein heterooligomerizationsearch transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch
B, D (P68871) hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch extracellular regionsearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch transportsearch bicarbonate transportsearch oxygen transportsearch regulation of blood vessel sizesearch renal absorptionsearch protein heterooligomerizationsearch blood coagulationsearch regulation of blood pressuresearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch nitric oxide transportsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch