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Structure of deoxy-quaternary haemoglobin with liganded beta subunits

The structure was published by Luisi, B., Liddington, B., Fermi, G., and Shibayama, N., in 1990 in a paper entitled "Structure of deoxy-quaternary haemoglobin with liganded beta subunits." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1990.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch metal ion bindingsearch heme bindingsearch oxygen bindingsearch endocytic vesicle lumensearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch membranesearch extracellular regionsearch cytosolsearch blood microparticlesearch cytosolic small ribosomal subunitsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch transportsearch oxygen transportsearch response to hydrogen peroxidesearch bicarbonate transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch
B, D (P68871) oxygen transporter activitysearch protein bindingsearch hemoglobin bindingsearch metal ion bindingsearch oxygen bindingsearch peroxidase activitysearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch blood coagulationsearch oxygen transportsearch bicarbonate transportsearch renal absorptionsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch regulation of blood pressuresearch oxidation-reduction processsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch transportsearch platelet aggregationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch