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Structure of deoxy-quaternary haemoglobin with liganded beta subunits

The structure was published by Luisi, B., Liddington, B., Fermi, G., and Shibayama, N., in 1990 in a paper entitled "Structure of deoxy-quaternary haemoglobin with liganded beta subunits." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1990.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch membranesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch cytosolic small ribosomal subunitsearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch oxygen bindingsearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen transportsearch bicarbonate transportsearch receptor-mediated endocytosissearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch
B, D (P68871) extracellular exosomesearch extracellular regionsearch hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch heme bindingsearch iron ion bindingsearch protein bindingsearch hemoglobin bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch renal absorptionsearch oxidation-reduction processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch small molecule metabolic processsearch regulation of blood pressuresearch blood coagulationsearch nitric oxide transportsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch platelet aggregationsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch