1ng2 Summary


Structure of autoinhibited p47phox

The structure was published by Groemping, Y., Lapouge, K., Smerdon, S.J., and Rittinger, K., in 2003 in a paper entitled "Molecular basis of phosphorylation-induced activation of the NADPH oxidase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Neutrophil cytosolic factor 1. This molecule has the UniProt identifier P14598 (NCF1_HUMAN)search. The sample contained 193 residues which is < 90% of the natural sequence. Out of 193 residues 176 were observed and are deposited in the PDB.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Neutrophil cytosolic factor 1 P14598 (156-340) (NCF1_HUMAN)search Homo sapienssearch < 90% 193 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14598 (156 - 340) Neutrophil cytosolic factor 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch SH3 domainsearch, NADPH oxidase subunit p47Phox, C terminal domainsearch
Chain InterPro annotation
A SH3 domainsearch