1nf1 Summary

pdbe.org/1nf1
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THE GAP RELATED DOMAIN OF NEUROFIBROMIN

The structure was published by Scheffzek, K., Ahmadian, M.R., Wiesmuller, L., et al., Stege, P., Schmitz, F., and Wittinghofer, A., in 1998 in a paper entitled "Structural analysis of the GAP-related domain from neurofibromin and its implications." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (NEUROFIBROMIN). This molecule has the UniProt identifier P21359 (NF1_HUMAN)search. The sample contained 333 residues which is < 90% of the natural sequence. Out of 333 residues 243 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (NEUROFIBROMIN) P21359 (1198-1551) (NF1_HUMAN)search Homo sapienssearch < 90% 333 78%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P21359 (1198 - 1551) PROTEIN (NEUROFIBROMIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A p120GAP domain-likesearch GTPase Activation - p120gap; domain 1search GTPase-activator protein for Ras-like GTPasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P21359) regulation of small GTPase mediated signal transductionsearch positive regulation of Ras GTPase activitysearch signal transductionsearch intracellularsearch Ras GTPase activator activitysearch GTPase activator activitysearch

Chain InterPro annotation
A Ras GTPase-activating proteinsearch Rho GTPase activation proteinsearch Ras GTPase-activating protein, conserved sitesearch Neurofibrominsearch