1nca Summary

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REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE-NC41 FAB COMPLEX

The structure was published by Tulip, W.R., Varghese, J.N., Laver, W.G., Webster, R.G., and Colman, P.M., in 1992 in a paper entitled "Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), and IGG2A-KAPPA NC41 FAB (HEAVY CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
N INFLUENZA A SUBTYPE N9 NEURAMINIDASE P03472 (82-470) (NRAM_I75A5)search Influenza A virus (A/tern/Australia/G70C/1975(H11N9))search < 90% 389 100%
L IGG2A-KAPPA NC41 FAB (LIGHT CHAIN) Not available
Mus musculussearch Not available 214 100%
H IGG2A-KAPPA NC41 FAB (HEAVY CHAIN) P01865 (1-100) (GCAM_MOUSE)search Mus musculussearch < 90% 221 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03472 (82 - 470) INFLUENZA A SUBTYPE N9 NEURAMINIDASE Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
P01865 (1 - 100) IGG2A-KAPPA NC41 FAB (HEAVY CHAIN) Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
N Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch
L V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch
H V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch Immunoglobulin C1-set domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
N (P03472) carbohydrate metabolic processsearch virion membranesearch host cell membranesearch membranesearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
N Glycoside hydrolase, family 34search Sialidasessearch
L Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch