1nb5 Summary

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Crystal structure of stefin A in complex with cathepsin H

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Jenko, S., Dolenc, I., Guncar, G., Dobersek, A., Podobnik, M., and Turk, D., in 2003 in a paper entitled "Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Cathepsin H, Cathepsin H MINI CHAIN, and STEFIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin H O46427 (116-334) (CATH_PIG)search Sus scrofasearch < 90% 220 100%
B Cathepsin H O46427 (116-334) (CATH_PIG)search Sus scrofasearch < 90% 220 100%
C Cathepsin H O46427 (116-334) (CATH_PIG)search Sus scrofasearch < 90% 220 100%
D Cathepsin H O46427 (116-334) (CATH_PIG)search Sus scrofasearch < 90% 220 100%
P Cathepsin H MINI CHAIN O46427 (98-105) (CATH_PIG)search Sus scrofasearch < 90% 8 100%
R Cathepsin H MINI CHAIN O46427 (98-105) (CATH_PIG)search Sus scrofasearch < 90% 8 100%
S Cathepsin H MINI CHAIN O46427 (98-105) (CATH_PIG)search Sus scrofasearch < 90% 8 100%
T Cathepsin H MINI CHAIN O46427 (98-105) (CATH_PIG)search Sus scrofasearch < 90% 8 100%
I STEFIN A P01040 (1-98) (CYTA_HUMAN)search Homo sapienssearch 100% 98 100%
J STEFIN A P01040 (1-98) (CYTA_HUMAN)search Homo sapienssearch 100% 98 100%
K STEFIN A P01040 (1-98) (CYTA_HUMAN)search Homo sapienssearch 100% 98 100%
L STEFIN A P01040 (1-98) (CYTA_HUMAN)search Homo sapienssearch 100% 98 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O46427 (116 - 334) Cathepsin H Sus scrofa
P01040 (1 - 98) STEFIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Papain-likesearch Cysteine proteinasessearch Papain family cysteine proteasesearch
P, R, S, T Papain-likesearch
I, J, K, L (P01040) Cystatinssearch Nuclear Transport Factor 2; Chain: A,search PF00031: Cystatin domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (O46427) proteolysissearch cysteine-type peptidase activitysearch
I, J, K, L (P01040) negative regulation of peptidase activitysearch negative regulation of endopeptidase activitysearch cell adhesionsearch keratinocyte differentiationsearch negative regulation of proteolysissearch single organismal cell-cell adhesionsearch peptide cross-linkingsearch cysteine-type endopeptidase inhibitor activitysearch endopeptidase inhibitor activitysearch structural molecule activitysearch peptidase inhibitor activitysearch protein binding, bridgingsearch protease bindingsearch cytoplasmsearch intracellularsearch cornified envelopesearch extracellular spacesearch extracellular vesicular exosomesearch nucleussearch

Chain InterPro annotation
A, B, C, D Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch
P, R, S, T
I, J, K, L Proteinase inhibitor I25, cystatinsearch Proteinase inhibitor I25A, stefin Asearch Proteinase inhibitor I25, cystatin, conserved sitesearch