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Crystal structure of stefin A in complex with cathepsin H

Source organisms:
Biochemical function: peptidase inhibitor activity
Biological process: cell-cell adhesion
Cellular component: peptidase inhibitor complex

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EC 3.4.22.16: Cathepsin H

Reaction catalysed:
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|- bonds) as well as an endopeptidase.
Systematic name:
-
Alternative Name(s):
  • Aleurain
  • Benzoylarginine-naphthylamide (BANA) hydrolase
  • Cathepsin B(3)
  • Cathepsin B3
  • Cathepsin BA
  • Cathepsin Ba
  • N-benzoylarginine-beta-naphthylamide hydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00031
Domain description: Cystatin domain
Occurring in:
  1. Cystatin-A
The deposited structure of PDB entry 1nb5 contains 4 copies of Pfam domain PF00031 (Cystatin domain) in Cystatin-A. Showing 1 copy in chain C [auth I].

PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin H
The deposited structure of PDB entry 1nb5 contains 4 copies of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin H. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001713
Domain description: Proteinase inhibitor I25A, stefin
Occurring in:
  1. Cystatin-A
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin H
IPR000010
Domain description: Cystatin domain
Occurring in:
  1. Cystatin-A
IPR018073
Domain description: Proteinase inhibitor I25, cystatin, conserved site
Occurring in:
  1. Cystatin-A
IPR046350
Domain description: Cystatin superfamily
Occurring in:
  1. Cystatin-A
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin H
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin H
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Cathepsin H
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin H
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Cathepsin H
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin H

Structure domains

CATH CATH domains
3.10.450.10
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Nuclear Transport Factor 2; Chain: A,
Occurring in:
  1. Cystatin-A
The deposited structure of PDB entry 1nb5 contains 4 copies of CATH domain 3.10.450.10 (Nuclear Transport Factor 2; Chain: A,) in Cystatin-A. Showing 1 copy in chain C [auth I].
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cathepsin H
The deposited structure of PDB entry 1nb5 contains 4 copies of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cathepsin H. Showing 1 copy in chain A.
SCOP SCOP annotations
54002
Class: Alpha and beta proteins (a+b)
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Occurring in:
  1. Cathepsin H
  2. Cathepsin H mini chain
The deposited structure of PDB entry 1nb5 contains 4 copies of SCOP domain 54002 (Papain-like) in Cathepsin H. Showing 1 copy in chain A.
54407
Class: Alpha and beta proteins (a+b)
Fold: Cystatin-like
Superfamily: Cystatin/monellin
Occurring in:
  1. Cystatin-A
The deposited structure of PDB entry 1nb5 contains 4 copies of SCOP domain 54407 (Cystatins) in Cystatin-A. Showing 1 copy in chain C [auth I].

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