1nax Summary


Thyroid receptor beta1 in complex with a beta-selective ligand

The structure was published by Ye, L., Li, Y.L., Mellstrom, K., et al., Sleph, P.G., George, R., and Malm, J., in 2003 in a paper entitled "Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Thyroid hormone receptor beta-1. This molecule has the UniProt identifier P10828 (THB_HUMAN)search. The sample contained 252 residues which is < 90% of the natural sequence. Out of 252 residues 250 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Thyroid hormone receptor beta-1 P10828 (209-460) (THB_HUMAN)search Homo sapienssearch < 90% 252 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10828 (209 - 460) Thyroid hormone receptor beta-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P10828) steroid hormone receptor activitysearch thyroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch