PDB 1nax biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Thyroid hormone receptor beta
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Multimeric state: monomeric

Accessible surface area: 12173.3 Å²

Buried surface area: 793.14 Å²

Dissociation area: 396.57 Å²

Dissociation energy (ΔG^diss): 2.86 kcal/mol

Dissociation entropy (TΔS^diss): 4.56 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-145480

$Monomeric assembly 1 of PDB entry 1nax coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thyroid hormone receptor beta;</li> <li class='image_legend_li'>1 copy of {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 1nax coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thyroid hormone receptor beta;</li> <li class='image_legend_li'>1 copy of {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 1nax coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thyroid hormone receptor beta;</li> <li class='image_legend_li'>1 copy of {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Thyroid hormone receptor beta
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Multimeric state: homo dimer

Accessible surface area: 22312.26 Å²

Buried surface area: 3623.96 Å²

Dissociation area: 1,017.9 Å²

Dissociation energy (ΔG^diss): 12.46 kcal/mol

Dissociation entropy (TΔS^diss): 13.28 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-145484

$Homo dimeric assembly 2 of PDB entry 1nax coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Thyroid hormone receptor beta;</li> <li class='image_legend_li'>2 copies of {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 1nax coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Thyroid hormone receptor beta;</li> <li class='image_legend_li'>2 copies of {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 1nax coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Thyroid hormone receptor beta;</li> <li class='image_legend_li'>2 copies of {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

Macromolecules

Thyroid hormone receptor beta

Chain: A
Length: 252 amino acids
Theoretical weight: 28.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P10828 (Residues: 209-460; Coverage: 55%)

Gene names: ERBA2, NR1A2, THR1, THRB
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:

Nuclear hormone receptor-like domain superfamily
Thyroid hormone receptor
Nuclear hormone receptor, ligand-binding domain
Nuclear hormone receptor

CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain

Thyroid hormone receptor beta in PDB entry 1nax, assembly 1, front view.

Thyroid hormone receptor beta in PDB entry 1nax, assembly 1, side view.

Thyroid hormone receptor beta in PDB entry 1nax, assembly 1, top view.

FASTA Sequence


    >pdb|1nax|A

GHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE

PDBe-KB: UniProt Coverage View: P10828

Molecule details ›

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FASTA (Protein chains A)
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PDBML
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Structure Factors
SIFTS XML file with residue-level mappings

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BLAST P10828 (UniProt)

Protein Data Bank in Europe

Thyroid receptor beta1 in complex with a beta-selective ligand

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 1nax › Structure analysis

Thyroid receptor beta1 in complex with a beta-selective ligand

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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1nax › Structure analysis