› 1nab

X-ray diffraction
2.15Å resolution

The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes

Released:
DOI: 10.2210/pdb1nab/pdb
PDB entry 1nab coloured by chain, front view.
PDB entry 1nab coloured by chain, side view.
PDB entry 1nab coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes.
Temperini C, Messori L, Orioli P, Di Bugno C, Animati F, Ughetto G
Nucleic Acids Res 31 1464-9 (2003)
PMID: 12595554

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114239 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*AP*TP*CP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 44D 2 x 44D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P43212
Unit cell:
a: 37.813Å b: 37.813Å c: 63.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.266 0.224 0.233
Expression system: Not provided

Quick links

Citations

6 review citations

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity.
Minotti et al. (2004)
5 more

8 mentions without citation

Unraveling the sequence-dependent polymorphic behavior of d(CpG) steps in B-DNA.
Dans et al. (2014)
7 more