1na7 Summary


Crystal structure of the catalytic subunit of human protein kinase CK2

The structure was published by Pechkova, E., Zanotti, G., and Nicolini, C., in 2003 in a paper entitled "Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Casein kinase II, alpha chain. This molecule has the UniProt identifier P68400 (CSK21_HUMAN)search. The sample contained 329 residues which is < 90% of the natural sequence. Out of 329 residues 326 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Casein kinase II, alpha chain P68400 (1-329) (CSK21_HUMAN)search Homo sapienssearch 100% 329 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P68400 (1 - 329) Casein kinase II, alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P68400) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P68400) protein phosphorylationsearch protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch