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EBI PDBe PDBeView

PDBe Entry: 1n9a view

Farnesyltransferase complex with tetrahydropyridine inhibitors
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.2 Å, R-factor: 32.9%, Free R-factor: 37.5%, Spacegroup: P 61
Released 07/01/2003, deposition: 22/11/2002, last revision: 24/02/2009
Authors Gwaltney II, S.L.search; O'Conner, S.J.search; Nelson, L.T.search; Sullivan, G.M.search; Imade, H.search; Wang, W.search; Hasvold, L.search; Li, Q.search; Cohen, J.search; Gu, W.Z.search
Primary citation Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
BIOORG.MED.CHEM.LETT.search vol:13, pag:1363-1366 (2003) [PubMed ID 12657283 ]search
Keywords Farnesyltransferasesearch, tetrahydropyridinesearch, Prenyltransferasesearch
EC 2.5.1.58 ExPASy BRENDA search (A B), 2.5.1.59 ExPASy BRENDA search (A)
Organism Rattus norvegicus(Norway rat) 10116search(A B)
UniProt Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) Q04631search (A)
Protein farnesyltransferase subunit beta (EC 2.5.1.58) (FTase-beta) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) Q02293search (B)
Related entries 1n94, 1n95
Polymers
Id Name Type UniProt Residues Observed
A Protein farnesyltransferase alpha subunit Protein Q04631 (FNTA_RAT)search
 315 99%
B Protein farnesyltransferase beta subunit Protein Q02293 (FNTB_RAT)search
 402 99%
Heterogens
Id Name Ligands
B ZINC ION ZN search
B ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID HFP search
B 1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE FTI search
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