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EBI PDBe PDBeView

PDBe Entry: 1n94 view

Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.5 Å, R-factor: 29.5%, Free R-factor: 29.6%, Spacegroup: P 61
Released 07/01/2003, deposition: 22/11/2002, last revision: 24/02/2009
Authors Gwaltney II, S.L.search; O'Connor, S.J.search; Nelson, L.T.search; Sullivan, G.M.search; Imade, H.search; Wang, W.search; Hasvold, L.search; Li, Q.search; Cohen, J.search; Gu, W.Z.search
Primary citation Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
BIOORG.MED.CHEM.LETT.search vol:13, pag:1359-1362 (2003) [PubMed ID 12657282 ]search
Keywords Farnesyltransferasesearch, Prenyltransferasesearch
EC 2.5.1.58 ExPASy BRENDA search (A B), 2.5.1.59 ExPASy BRENDA search (A)
Organism Rattus norvegicus(Norway rat) 10116search(A B)
UniProt Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) Q04631search (A)
Protein farnesyltransferase subunit beta (EC 2.5.1.58) (FTase-beta) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) Q02293search (B)
Related entries 1n95, 1n9a
Polymers
Id Name Type UniProt Residues Observed
A Protein farnesyltransferase alpha subunit Protein Q04631 (FNTA_RAT)search
 315 100%
B Protein farnesyltransferase beta subunit Protein Q02293 (FNTB_RAT)search
 397 100%
Heterogens
Id Name Ligands
B ZINC ION ZN search
A ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID HFP search
A 2-{(5-{[BUTYL-(2-CYCLOHEXYL-ETHYL)-AMINO]-METHYL}-2'-METHYL-BIPHENYL-2-CARBONYL)-AMINO]-4-METHYLSULFANYL-BUTYRIC ACID TIN search
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