1n8z Summary

pdbe.org/1n8z
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Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab

The structure was published by Cho, H.-S., Mason, K., Ramyar, K.X., et al., Gabelli, S.B., Denney Jr., D.W., and Leahy, D.J., in 2003 in a paper entitled "Structure of the Extracellular Region of HER2 Alone and in Complex with the Herceptin Fab" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.52 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Herceptin Fab (antibody) - light chain, Herceptin Fab (antibody) - heavy chain, and Receptor protein-tyrosine kinase erbB-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Herceptin Fab (antibody) - light chain Not available
Mus musculussearch, Homo sapienssearch Not available 214 100%
B Herceptin Fab (antibody) - heavy chain Not available
Mus musculussearch, Homo sapienssearch Not available 220 100%
C Receptor protein-tyrosine kinase erbB-2 P04626 (23-629) (ERBB2_HUMAN)search Homo sapienssearch < 90% 607 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04626 (23 - 629) Receptor protein-tyrosine kinase erbB-2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch
B V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch
C L domainsearch, Growth factor receptor domainsearch 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
C (P04626) transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch membranesearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch

Chain InterPro annotation
A Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
B Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
C EGF receptor, L domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch