1n8y Summary


Crystal structure of the extracellular region of rat HER2

The structure was published by Cho, H.-S., Mason, K., Ramyar, K.X., et al., Gabelli, S.B., Denney Jr., D.W., and Leahy, D.J., in 2003 in a paper entitled "Structure of the Extracellular Region of HER2 Alone and in complex with the Herceptin Fab" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of protooncoprotein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C protooncoprotein P06494 (23-631) (ERBB2_RAT)search Rattus norvegicussearch < 90% 608 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06494 (23 - 631) protooncoprotein Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C L domainsearch, Growth factor receptor domainsearch 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
C (P06494) ATP bindingsearch transmembrane receptor protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
C EGF receptor, L domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch