› 1n8y

X-ray diffraction
2.4Å resolution

Crystal structure of the extracellular region of rat HER2

Released:
DOI: 10.2210/pdb1n8y/pdb
PDB entry 1n8y coloured by chain, front view.
PDB entry 1n8y coloured by chain, side view.
PDB entry 1n8y coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.
Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Leahy DJ
Nature 421 756-60 (2003)
PMID: 12610629

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139066 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Receptor tyrosine-protein kinase erbB-2 Chain: C
Molecule details ›
Chain: C
Length: 608 amino acids
Theoretical weight: 67.36 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06494 (Residues: 23-631; Coverage: 49%)
Gene names: Erbb2, Neu
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 130.87Å b: 116.4Å c: 55.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.224 0.282
Expression system: Cricetulus griseus

Quick links

Citations

255 review citations

ERBB receptors and cancer: the complexity of targeted inhibitors.
Hynes et al. (2005)
254 more

8 mentions without citation

Activating HER2 mutations in HER2 gene amplification negative breast cancer.
Bose et al. (2013)
7 more