1n8o Summary

pdbe.org/1n8o
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Crystal structure of a complex between bovine chymotrypsin and ecotin

A publication describing this structure is not available. The depositing authors are Cambillau, C.search; Spinelli, S.search; Lauwereys, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This entry contains 8 copies of 4 unique biopolymers (complete list).

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Chymotrypsin A, A chain P00766 (1-13) (CTRA_BOVIN)search Bos taurussearch 94% 13 84%
B Chymotrypsin A, b chain P00766 (16-146) (CTRA_BOVIN)search Bos taurussearch 94% 131 100%
C Chymotrypsin A, C chain P00766 (149-245) (CTRA_BOVIN)search Bos taurussearch 94% 97 100%
E ecotin P23827 (21-162) (ECOT_ECOLI)search Escherichia coli K-12search 100% 142 95%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00766 (1 - 13) Chymotrypsin A, A chain Bos taurus
P23827 (21 - 162) ecotin Escherichia coli K-12

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00766) Eukaryotic proteasessearch
B (P00766) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
C (P00766) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
E (P23827) Ecotin, trypsin inhibitorsearch Immunoglobulin-likesearch PF03974: Ecotinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
B (P00766) catalytic activitysearch serine-type endopeptidase activitysearch proteolysissearch
C (P00766) serine-type endopeptidase activitysearch catalytic activitysearch proteolysissearch
E (P23827) protein bindingsearch serine-type endopeptidase inhibitor activitysearch peptidase inhibitor activitysearch negative regulation of endopeptidase activitysearch negative regulation of peptidase activitysearch periplasmic spacesearch outer membrane-bounded periplasmic spacesearch

Chain InterPro annotation
A
B Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
C Peptidase S1search Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
E Proteinase inhibitor I11, ecotinsearch Proteinase inhibitor I11, ecotin, gammaproteobacteriasearch Proteinase inhibitor I11, ecotin domainsearch Ecotin, C-terminalsearch