1n83 Summary


Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol

The structure was published by Kallen, J.A., Schlaeppi, J.M., Bitsch, F., et al., Geiser, M., Delhon, I., and Fournier, B., in 2002 in a paper entitled "X-ray Structure of hROR(alpha) LBD at 1.63A: Structural and Functional data that Cholesterol or a Cholesterol derivative is the natural ligand of ROR(alpha)" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.63 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Nuclear receptor ROR-alpha. This molecule has the UniProt identifier P35398 (RORA_HUMAN)search. The sample contained 270 residues which is < 90% of the natural sequence. Out of 270 residues 251 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Nuclear receptor ROR-alpha P35398 (271-523) (RORA_HUMAN)search Homo sapienssearch < 90% 270 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35398 (271 - 523) Nuclear receptor ROR-alpha Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35398) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear receptor RORsearch Nuclear hormone receptor, ligand-bindingsearch