› 1n44

X-ray diffraction
3Å resolution

Crystal Structure of Annexin V R23E Mutant

Released:
DOI: 10.2210/pdb1n44/pdb
PDB entry 1n44 coloured by chain, front view.
PDB entry 1n44 coloured by chain, side view.
PDB entry 1n44 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces.
Mo Y, Campos B, Mealy TR, Commodore L, Head JF, Dedman JR, Seaton BA
J Biol Chem 278 2437-43 (2003)
PMID: 12401794

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A5 Chain: A
Molecule details ›
Chain: A
Length: 319 amino acids
Theoretical weight: 35.76 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P14668 (Residues: 1-319; Coverage: 100%)
Gene names: Anx5, Anxa5
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: R3
Unit cell:
a: 157.757Å b: 157.757Å c: 36.761Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.163 0.241
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Evolutionary adaptation of plant annexins has diversified their molecular structures, interactions and functional roles.
Clark et al. (2012)
2 more