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PDBe Entry: 1n1m view

Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.5 Å, R-factor: 21.1%, Free R-factor: 26.3%, Spacegroup: P 21 21 21
Released 27/12/2002, deposition: 18/10/2002, last revision: 24/02/2009
Authors Rasmussen, H.B.search; Branner, S.search; Wiberg, F.C.search; Wagtmann, N.R.search
Primary citation Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analogue
NAT.STRUCT.BIOL.search vol:10, pag:19-25 (2003) [PubMed ID 12483204 ]search
Keywords alpha/betasearch, beta-propellersearch, dimersearch, HYDROLASEsearch
EC 3.4.14.5 ExPASy BRENDA search (A B)
Organism Homo sapiens(human) 9606search(A B)
UniProt Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) [Contains: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] P27487search (A B)
Solvent A, B
Polymers
Id Name Type UniProt Residues Observed
A, B Dipeptidyl peptidase IV SOLUBLE FORM Protein P27487 (DPP4_HUMAN)search
728 100%
Heterogens
Id Name Ligands
A NAG-NAG-FUC NAG search NDG search FUC search
A SUGAR (3-MER) NDG search NAG search FUC search
A NAG-NAG NAG search
A NAG-NAG-MAN NAG search NDG search MAN search
A, B SUGAR (N-ACETYL-D-GLUCOSAMINE) NAG search
B NAG-FUC NAG search FUC search
B SUGAR (2-MER) NDG search NAG search
B SUGAR (3-MER) NAG search BMA search
B SUGAR (2-MER) NDG search
A, B MERCURY (II) ION HG search
A, B 2-AMINO-3-METHYL-1-PYRROLIDIN-1-YL-BUTAN-1-ONE A3M search
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