› 1n1f

X-ray diffraction
1.95Å resolution

Crystal Structure of Human Interleukin-19

Released:
DOI: 10.2210/pdb1n1f/pdb
PDB entry 1n1f coloured by chain, front view.
PDB entry 1n1f coloured by chain, side view.
PDB entry 1n1f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.
Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A
J Biol Chem 278 3308-13 (2003)
PMID: 12403790

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193740 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-19 Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 18.39 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9UHD0 (Residues: 19-177; Coverage: 100%)
Gene names: IL19, ZMDA1
Sequence domains: Interleukin 10
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 30.657Å b: 52.974Å c: 93.474Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.156 0.243
Expression system: Drosophila melanogaster

Quick links

Citations

22 review citations

Interleukin-10 and related cytokines and receptors.
Pestka et al. (2004)
21 more

7 mentions without citation

Structural analysis of cytokines comprising the IL-10 family.
Zdanov A. (2010)
6 more