1mzn Summary

pdbe.org/1mzn
spacer

CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO THE SYNTHETIC AGONIST COMPOUND BMS 649 AND A COACTIVATOR PEPTIDE

The structure was published by Egea, P.F., Mitschler, A., and Moras, D., in 2002 in a paper entitled "Molecular Recognition of Agonist Ligands by RXRs" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely RXR retinoid X receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RXR retinoid X receptor P19793 (223-462) (RXRA_HUMAN)search Homo sapienssearch 98% 240 93%
C RXR retinoid X receptor P19793 (223-462) (RXRA_HUMAN)search Homo sapienssearch 98% 240 93%
E RXR retinoid X receptor P19793 (223-462) (RXRA_HUMAN)search Homo sapienssearch 98% 240 93%
G RXR retinoid X receptor P19793 (223-462) (RXRA_HUMAN)search Homo sapienssearch 98% 240 93%
B Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 84%
D Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 84%
F Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 84%
H Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 84%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19793 (223 - 462) RXR retinoid X receptor Homo sapiens
Q15596 (686 - 698) Nuclear receptor coactivator 2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P19793) Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch
B, D, F, H Steroid receptor coactivatorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C, E, G (P19793) nucleussearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch zinc ion bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, C, E, G Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B, D, F, H Nuclear receptor coactivator Src-1search