1mxe Summary

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Structure of the Complex of Calmodulin with the Target Sequence of CaMKI

The structure was published by Clapperton, J.A., Martin, S.R., Smerdon, S.J., Gamblin, S.J., and Bayley, P.M., in 2002 in a paper entitled "Structure of the Complex of Calmodulin with the Target Sequence of Calmodulin-Dependent Protein Kinase I: Studies of the Kinase Activation Mechanism" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calmodulin and Target Sequence of rat Calmodulin-Dependent Protein Kinase I.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62152 (2-149) (CALM_DROME)search Drosophila melanogastersearch 99% 148 97%
B Calmodulin P62152 (2-149) (CALM_DROME)search Drosophila melanogastersearch 99% 148 97%
E Target Sequence of rat Calmodulin-Dependent Protein Kinase I Q63450 (294-318) (KCC1A_RAT)search Rattus norvegicussearch < 90% 25 100%
F Target Sequence of rat Calmodulin-Dependent Protein Kinase I Q63450 (294-318) (KCC1A_RAT)search Rattus norvegicussearch < 90% 25 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62152 (2 - 149) Calmodulin Drosophila melanogaster
Q63450 (294 - 318) Target Sequence of rat Calmodulin-Dependent Protein Kinase I

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62152) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
E, F

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P62152) lateral inhibitionsearch spindle assembly involved in mitosissearch photoreceptor cell axon guidancesearch regulation of response to DNA damage stimulussearch centriole replicationsearch mitotic spindle organizationsearch muscle cell cellular homeostasissearch sensory perception of soundsearch adaptation of rhodopsin mediated signalingsearch rhodopsin mediated signaling pathwaysearch rhabdomere developmentsearch protein phosphorylationsearch metarhodopsin inactivationsearch deactivation of rhodopsin mediated signalingsearch actin filament-based movementsearch positive regulation of NFAT protein import into nucleussearch regulation of light-activated channel activitysearch kinetochore organizationsearch myosin V bindingsearch protein bindingsearch calcium ion bindingsearch calmodulin bindingsearch myosin VI head/neck bindingsearch metal ion bindingsearch myosin heavy chain bindingsearch cytoplasmsearch spindle polesearch microtubule associated complexsearch centriolesearch spindlesearch rhabdomeresearch myosin V complexsearch midbodysearch myosin VI complexsearch

Chain InterPro annotation
A, B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
E, F